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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia
Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang
《医学前沿(英文)》 2019年 第13卷 第3期 页码 388-397 doi: 10.1007/s11684-018-0624-1
关键词: AML1–ETO c-KIT homoharringtonine oridonin t(8 21) AML synergistic effect
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
null
《医学前沿(英文)》 2012年 第6卷 第3期 页码 248-262 doi: 10.1007/s11684-012-0206-6
The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.
关键词: AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+
CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21
Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang
《医学前沿(英文)》 2021年 第15卷 第4期 页码 608-620 doi: 10.1007/s11684-021-0836-7
关键词: t(8 21)(q22 q22) AML CD34+CD117dim/ CD34+CD117bri cell population gene expression prognosis
赵宪文
《中国工程科学》 1999年 第1卷 第3期 页码 16-21
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 25-30 doi: 10.1007/s11684-013-0244-8
Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.
关键词: FGF21 metabolism pharmacology physiology clinical relevance
陈俊武
《中国工程科学》 2000年 第2卷 第4期 页码 21-24
蒋正华
《中国工程科学》 2002年 第4卷 第4期 页码 1-11
从管理学角度回顾了过去百年的世界历史,研究新世纪可能发生的进步,并探讨更好地建立 世界和平与合作,实现共同发展的方案。
Digital manufacturing—the development direction of the manufacturing technology in the 21st century
XIONG You-lun, YIN Zhou-ping
《机械工程前沿(英文)》 2006年 第1卷 第2期 页码 125-130 doi: 10.1007/s11465-006-0021-3
关键词: development foundation multi-discipline scientific supporting
How diplomacy saved the COP21 Paris Climate Conference, but now, can we save ourselves?
D. Nathaniel MULCAHY, David L. MULCAHY
《能源前沿(英文)》 2018年 第12卷 第3期 页码 344-352 doi: 10.1007/s11708-017-0498-y
To solve a problem, three things are necessary: awareness, means, and will. The 2015 COP21 Paris accord was a masterful, perhaps even world-saving, diplomatic advance toward making the world aware of climate change. Some of that success may have been because publications from the IPCC and the National Academy of Science were made available, on line, as prepublication offerings, in order to be widely viewed before the Paris Climate Conference. This provided diplomats and negotiators with the latest information about climate change, its nearness in time, its consequences, and how well current mitigation technologies can succeed. Whatever the reasons, the Paris Climate Conference, was a success. Leaders of 195 nations agreed that climate change is a real and present danger to life as is known to all. This important understanding was accomplished despite the presentation of well established scientific facts which, without very diplomatic handling, could easily have evoked overwhelming political opposition to an agreement and thus another COP failure. In this paper, the fact that how some scientific truths, written specifically to be overlooked, were presented in order to prepare COP21 participants for the conference is explained. Besides, the effectiveness and efficiency of currently favored mitigation policies, the extent of ongoing progress to better ones, and finally, how a new appreciation of climate change consequences can strengthen the will of nation states and industries to work toward solutions are evaluated.
Silk Roads for the 21st Century: Engineering Mega-Infrastructure for Development and Sustainability
Tony Marjoram
《工程管理前沿(英文)》 2016年 第3卷 第3期 页码 187-196 doi: 10.15302/J-FEM-2016038
关键词: infrastructure growth development sustainability change new Silk Roads
赵淳生
《中国工程科学》 2002年 第4卷 第2期 页码 86-91
叙述了新型微特电机——超声电机的特点,回顾了20世纪末期超声电机的发展和应用情况,介绍了南京航空航天大学超声电机研究中心在超声电机研究方面的进展,预测了21世纪国内外市场对超声电机技术的需求
标题 作者 时间 类型 操作
Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia
Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang
期刊论文
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
null
期刊论文
CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21
Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang
期刊论文
Digital manufacturing—the development direction of the manufacturing technology in the 21st century
XIONG You-lun, YIN Zhou-ping
期刊论文
How diplomacy saved the COP21 Paris Climate Conference, but now, can we save ourselves?
D. Nathaniel MULCAHY, David L. MULCAHY
期刊论文
Silk Roads for the 21st Century: Engineering Mega-Infrastructure for Development and Sustainability
Tony Marjoram
期刊论文